The image depicts a portrait of a woman in a three-quarter view. She is facing the viewer with her head slightly turned to her left. Her facial features include large eyes, a straight nose, and slightly parted lips. She has curly hair styled in soft waves cascading around her shoulders. The woman is wearing a patterned garment with a squared neckline and a single drop earring. The background is plain and dark, with the name "Mrs. Anne Killigrew" and the attribution "Painted by herself" inscribed below the portrait.