Ray Francis was a founding member of the Kamoinge Workshop. He received his first camera in 1952, at the age of 15. In 1961 he met Louis Draper, with whom he formed Group 35. In 1963 Group 35 merged with other photographers to create Kamoinge, where Francis contributed significantly by creating a darkroom for the group and working as a photo editor for the Black Photographers Annual.

His photographic work spanned still life, portraiture, and landscape, often using dramatic light and shadow, influenced by Johannes Vermeer’s use of composition. Francis also made contributions as an educator, teaching at the Bedford-Stuyvesant Neighborhood Youth Corps (1966–1969) and later serving as director of the New York City Board of Education’s photography program for Intermediate School 201 from 1970 to 1974.