James, 5th Duke of Hamilton, was renowned as a very handsome and graceful man, thus many portraits of him exist. A Tory who intrigued with the exiled Stuart dynasty, he was created a Knight of the Thistle in 1723 by the titular James III, and again in 1726 by George I. From 1727-1733 he held the post of Lord of the Bedchamber, resigning due to his opposition to Sir Robert Walpole. Sir James died in his fortieth year of jaundice and palsy. In his short life, he managed to marry three times; the first time on 14 February 1723 to Anne, daughter of the 4th Earl of Dundonald. They had a son, James, born 10 July 1724 (and who succeeded his father as 6th Duke of Hamilton and 3rd Duke of Brandon) but Anne died shortly thereafter, on 14 August. In 1727 he married Elizabeth, daughter and co-heir of Thomas Strangeways, of Melbury Sanford, Dorset; she died on 3 November 1729. The third marriage was to Anne [d.1771], wealthy daughter and co-heiress of Edward Spencer, of Rendlesham, Suffolk, on 21 August 1737. With her he had two more sons--Archibald, who later succeeded his nephew, Douglas, 8th Duke, as 9th Duke of Hamilton, and Spencer (later Lt.-Col.)--and a daughter, Anne. In 1751, James' widow married the Hon. Richard Savage Nassau, son of the 3rd Earl of Rochford.